Iron deficiency as energetic insult to skeletal muscle in chronic diseases
نویسندگان
چکیده
منابع مشابه
Skeletal Muscle Mitochondrial Energetic Efficiency and Aging
Aging is associated with a progressive loss of maximal cell functionality, and mitochondria are considered a key factor in aging process, since they determine the ATP availability in the cells. Mitochondrial performance during aging in skeletal muscle is reported to be either decreased or unchanged. This heterogeneity of results could partly be due to the method used to assess mitochondrial per...
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The effects of iron deficiency on the NADH- and succinate-oxidizing complexes of rat skeletal muscle mitochondria have been investigated. Both systems were similarly affected: activities were about 30% of normal in dehydrogenase, ubiquinone reductase, and oxidase assays, and similar reductions in the concentration of their respective flavin prosthetic groups were also evident in the iron-defici...
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Mitogen-Activated Protein Kinase (MAPK) pathway is a signal transduction pathway that functions in a wide range of physiological and pathophysiological cellular events including cell proliferation, differentiation, apoptosis, migration, inflammation, metabolic disorders and diseases. In skeletal muscle, it plays an essential role in muscle fiber specialization, muscle mass maintenance, damage i...
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Although elevation of the levels of serum alanine aminotransferase (ALT) following liver injury is well known, confusion exists concerning skeletal muscle injury as the cause of this rise. We reviewed the records of 16 patients who had muscle necrosis without evidence of liver disease. The patients were divided into three groups: extreme exercise, polymyositis, and seizures. All patients exhibi...
متن کاملMuscle specific iron deficiency has systemic consequences
Iron is an essential element for most prokaryotes and all eukaryotes. the skeletal muscle specific actin promoter driving the Cre recombinase Iron is required for heme synthesis, iron–sulfur cluster synthesis and as a co-factor for awide variety of enzymes.Most of the iron in vertebrates is found in hemoglobin in red blood cells and iron deficiency anemia is a significant medical problem. Iron,...
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ژورنال
عنوان ژورنال: Journal of Cachexia, Sarcopenia and Muscle
سال: 2018
ISSN: 2190-5991
DOI: 10.1002/jcsm.12314